GS PrelimsScience and TechnologyInheritance and Evolution1998

Haemophilia is a genetic disorder which leads to

A

decrease in haemoglobin level

B

rheumatic heart disease

C

decrease in WBC

D

non-clotting of blood

Correct Answer: Option D

Explanation

1. The question asks what Haemophilia, a genetic disorder, leads to. 2. Haemophilia is an inherited genetic disorder that impairs the body's ability to make blood clots, a process needed to stop bleeding. 3. This results from a deficiency in one of the blood clotting factors (Factor VIII in Haemophilia A, Factor IX in Haemophilia B). 4. Consequently, individuals with haemophilia experience prolonged bleeding after injury, easy bruising, and increased risk of bleeding inside joints or the brain. 5. Options analysis: (A) decrease in haemoglobin level (anemia) is not the primary feature. (B) rheumatic heart disease is unrelated. (C) decrease in WBC (leukopenia) is unrelated. (D) non-clotting of blood (or impaired clotting) is the defining characteristic of haemophilia. 6. Therefore, Haemophilia leads to non-clotting of blood (impaired blood clotting).

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