Of the four landmarks in medical history given below, which one was the first to take place?

1. The question asks to identify the earliest landmark among the given options in medical history. 2. Organ transplant (successful kidney transplant in 1954), Bypass surgery (developed significantly in the 1960s), and Test-tube baby (first successful birth in 1978) are all 20th-century advancements. 3. Plastic surgery, particularly reconstructive techniques like skin grafting and rhinoplasty (nose reconstruction), has ancient roots. Sushruta, an ancient Indian physician (around 600 BCE), described surgical procedures including plastic surgery in the Sushruta Samhita. 4. Therefore, Plastic surgery predates the other listed medical landmarks by centuries.