GS PrelimsScience and TechnologyBiotechnology2002

Match List I (Scientists) with List II I (Achievement) and select the correct answer using the codes given below the lists: List I (Scientists) - List II (Achievement) 1. A. Arber and Smith - 1. Developed transgenic plants with Agrobacterium T-DNA 2. B. Feldman - 2. Discovered endonucleases 3. C. Mullis - 3. Discovered reverse transcriptase 4. D. Temin and Baltimore - 4. Discovered polymerase chain reaction

A

A-2, B-1, C-4, D-3

B

A-1, B-2, C-4, D-3

C

A-2, B-1, C-3, D-4

D

A-1, B-2, C-3, D-4

Correct Answer: Option A

Explanation

1. This question requires matching Scientists with their key scientific Achievements/Discoveries. 2. A. Werner Arber, Hamilton O. Smith, and Daniel Nathans jointly won the Nobel Prize in 1978 for the discovery of restriction enzymes (endonucleases) and their application to problems of molecular genetics. These enzymes cut DNA at specific sites. Matches A with 2. 3. B. Marc Van Montagu and Jeff Schell, along with Mary-Dell Chilton's group (which included Michael Feldman in related work), pioneered methods for plant genetic engineering using Agrobacterium tumefaciens and its T-DNA to develop transgenic plants. Matches B with 1. 4. C. Kary Mullis won the Nobel Prize in 1993 for inventing the Polymerase Chain Reaction (PCR) technique, which allows for the amplification of specific DNA sequences. Matches C with 4. 5. D. Howard Temin and David Baltimore independently discovered the enzyme reverse transcriptase in 1970 (shared Nobel Prize in 1975 with Renato Dulbecco). This enzyme synthesizes DNA from an RNA template. Matches D with 3. 6. Therefore, the correct matching is A-2, B-1, C-4, D-3. [Self-correction: The provided answer is 'c' (A-2, B-1, C-3, D-4). Let's re-check. A-2 is correct. B-1 is correct. C-3 (Mullis - Discovered reverse transcriptase) is incorrect; Mullis discovered PCR. D-4 (Temin and Baltimore - Discovered PCR) is incorrect; they discovered reverse transcriptase. Option 'a' (A-2, B-1, C-4, D-3) has all the correct pairings based on scientific history. There is an error in the provided answer key 'c'. *Analysis proceeds assuming the correct historical matches (A-2, B-1, C-4, D-3) as represented in option 'a', despite the provided answer being 'c'.*]

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